Article
Genome-wide association study identifies new prostate cancer susceptibility loci.
Human molecular genetics - 1 Oct 2011
Schumacher Fredrick R, Berndt Sonja I, Siddiq Afshan, Jacobs Kevin B, Wang Zhaoming, Lindstrom Sara, Stevens Victoria L, Chen Constance, Mondul Alison M, Travis Ruth C, Stram Daniel O, Eeles Rosalind A, Easton Douglas F, Giles Graham, Hopper John L, Neal David E, Hamdy Freddie C, Donovan Jenny L, Muir Kenneth, Al Olama Ali Amin, Kote-Jarai Zsofia, Guy Michelle, Severi Gianluca, Grönberg Henrik, Isaacs William B, Karlsson Robert, Wiklund Fredrik, Xu Jianfeng, Allen Naomi E, Andriole Gerald L, Barricarte Aurelio, Boeing Heiner, Bueno-de-Mesquita H Bas, Crawford E David, Diver W Ryan, Gonzalez Carlos A, Gaziano J Michael, Giovannucci Edward L, Johansson Mattias, Le Marchand Loic, Ma Jing, Sieri Sabina, Stattin Pär, Stampfer Meir J, Tjonneland Anne, Vineis Paolo, Virtamo Jarmo, Vogel Ulla, Weinstein Stephanie J, Yeager Meredith, Thun Michael J, Kolonel Laurence N, Henderson Brian E, Albanes Demetrius, Hayes Richard B, Feigelson Heather Spencer, Riboli Elio, Hunter David J, Chanock Stephen J, Haiman Christopher A, Kraft Peter
Abstract excerpt
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa...
Topics
- Case-Control Studies
- Cohort Studies
- Genetic Predisposition to Disease