Article
Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses.
The Prostate - 15 May 2010
Christensen G Bryce, Baffoe-Bonnie Agnes B, George Asha, Powell Isaac, Bailey-Wilson Joan E, Carpten John D, Giles Graham G, Hopper John L, Severi Gianluca, English Dallas R, Foulkes William D, Maehle Lovise, Moller Pal, Eeles Ros, Easton Douglas, Badzioch Michael D, Whittemore Alice S, Oakley-Girvan Ingrid, Hsieh Chih-Lin, Dimitrov Latchezar, Xu Jianfeng, Stanford Janet L, Johanneson Bo, Deutsch Kerry, McIntosh Laura, Ostrander Elaine A, Wiley Kathleen E, Isaacs Sarah D, Walsh Patrick C, Isaacs William B, Thibodeau Stephen N, McDonnell Shannon K, Hebbring Scott, Schaid Daniel J, Lange Ethan M, Cooney Kathleen A, Tammela Teuvo L J, Schleutker Johanna, Paiss Thomas, Maier Christiane, Grönberg Henrik, Wiklund Fredrik, Emanuelsson Monica, Farnham James M, Cannon-Albright Lisa A, Camp Nicola J
Abstract excerpt
BACKGROUND: Prostate cancer (PC) is generally believed to have a strong inherited component, but the search for susceptibility genes has been hindered by the effects of genetic heterogeneity. The recently developed sumLINK and sumLOD statistics are powerful tools for linkage analysis in the presence of heterogeneity. METHODS: We performed a secondary analysis of 1,233 PC pedigrees from the International...
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