Article
Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG.
The Prostate - 1 Mar 2012
Lu Lingyi, Cancel-Tassin Geraldine, Valeri Antoine, Cussenot Olivier, Lange Ethan M, Cooney Kathleen A, Farnham James M, Camp Nicola J, Cannon-Albright Lisa A, Tammela Teuvo L J, Schleutker Johanna, Hoegel Josef, Herkommer Kathleen, Maier Christiane, Vogel Walther, Wiklund Fredrik, Emanuelsson Monica, Grönberg Henrik, Wiley Kathleen E, Isaacs Sarah D, Walsh Patrick C, Helfand Brian T, Kan Donghui, Catalona William J, Stanford Janet L, FitzGerald Liesel M, Johanneson Bo, Deutsch Kerry, McIntosh Laura, Ostrander Elaine A, Thibodeau Stephen N, McDonnell Shannon K, Hebbring Scott, Schaid Daniel J, Whittemore Alice S, Oakley-Girvan Ingrid, Hsieh Chih-Lin, Powell Isaac, Bailey-Wilson Joan E, Cropp Cheryl D, Simpson Claire, Carpten John D, Seminara Daniela, Zheng S Lilly, Xu Jianfen, Giles Graham G, Severi Gianluca, Hopper John L, English Dallas R, Foulkes William D, Maehle Lovise, Moller Pal, Badzioch Michael D, Edwards Steve, Guy Michelle, Eeles Ros, Easton Douglas, Isaacs William B
Abstract excerpt
BACKGROUND: In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite-based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis,...
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