Article
Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG).
Human genetics - 1 Jul 2012
Jin Guangfu, Lu Lingyi, Cooney Kathleen A, Ray Anna M, Zuhlke Kimberly A, Lange Ethan M, Cannon-Albright Lisa A, Camp Nicola J, Teerlink Craig C, Fitzgerald Liesel M, Stanford Janet L, Wiley Kathleen E, Isaacs Sarah D, Walsh Patrick C, Foulkes William D, Giles Graham G, Hopper John L, Severi Gianluca, Eeles Ros, Easton Doug, Kote-Jarai Zsofia, Guy Michelle, Rinckleb Antje, Maier Christiane, Vogel Walther, Cancel-Tassin Geraldine, Egrot Christophe, Cussenot Olivier, Thibodeau Stephen N, McDonnell Shannon K, Schaid Daniel J, Wiklund Fredrik, Grönberg Henrik, Emanuelsson Monica, Whittemore Alice S, Oakley-Girvan Ingrid, Hsieh Chih-Lin, Wahlfors Tiina, Tammela Teuvo, Schleutker Johanna, Catalona William J, Zheng S Lilly, Ostrander Elaine A, Isaacs William B, Xu Jianfeng
Abstract excerpt
Multiple prostate cancer (PCa) risk-related loci have been discovered by genome-wide association studies (GWAS) based on case-control designs. However, GWAS findings may be confounded by population stratification if cases and controls are inadvertently drawn from different genetic backgrounds. In addition, since these loci were identified in cases with predominantly sporadic disease, little is known about their...
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