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Article

Comparison of ultra-deep versus Sanger sequencing detection of minority mutations on the HIV-1 drug resistance interpretations after virological failure

2 Apr 2014

Abstract excerpt

OBJECTIVE: Drug-resistance mutations are routinely detected using standard Sanger sequencing, which does not detect minor variants with a frequency below 20%. The impact of detecting minor variants generated by ultra-deep sequencing (UDS) on HIV drug-resistance interpretations has not yet been studied. DESIGN: Fifty HIV-1 patients who experienced virological failure were included in this retrospective study....

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PMID: 24698843
DOI: 10.1097/qad.0000000000000267

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