Article
Resistance profile of HIV-1 quasispecies in patients under treatment failure using single molecule, real-time sequencing.
AIDS (London, England) - 1 Dec 2020
Monaco Daniela C, Zapata Lucas, Hunter Eric, Salomon Horacio, Dilernia Dario A
Abstract excerpt
OBJECTIVE: Short-read next-generation sequencing (NGS) has been implemented to study the resistance profile of HIV as it provides a higher sensitivity than Sanger sequencing. However, short-reads only generates a consensus view of the viral population rather than a reconstruction of the viral haplotypes. In this study, we evaluated the resistance profile of HIV quasispecies in patients undergoing treatment...
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