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Article

The relationship between ADAM17 promoter polymorphisms and sporadic Alzheimer's disease in a Northern Chinese Han population.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Oct 2010

Wang Min, Li Yang, Lu Yan, Zuo Xiumei, Wang Fen, Zhang Zhijun, Jia Jianping

Abstract excerpt

The deposition of amyloid beta peptides (Abeta) in the brain is crucial in the pathogenesis of Alzheimer's disease (AD). A disintegrin and metalloproteinase (ADAM) 17 cleaves the amyloid precursor protein (APP) within the Abeta sequence and, therefore, precludes the formation of neurotoxic Abeta....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20627730
DOI: 10.1016/j.jocn.2010.01.008

Genes

ADAM17
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20627730-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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