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Article

Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease.

Neurobiology of aging - 1 Jan 2011

Cong Lin, Jia Jianping

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the formation of amyloid beta-peptides (Aβ peptides) and their deposition in the brain. A disintegrin and metalloproteinase (ADAM) 9 can cleave the amyloid precursor protein (APP) within the Aβ domain and preclude generation of Aβ peptides. We systematically screened ADAM9 gene promoter region and found four polymorphisms:...

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Source

Identifiers

PMID: 19237226
DOI: 10.1016/j.neurobiolaging.2009.01.001

Genes

ADAM9
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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