Article
Genetic variability in ADAM17/TACE is associated with sporadic Alzheimer's disease risk, neuropsychiatric symptoms and cognitive performance on the Rey Auditory Verbal Learning and Clock Drawing Tests.
PloS one - 1 Jan 2025
Bruno Francesco, Aceto Mirella A, Paparazzo Ersilia, Arcuri Domenico, Vozzo Francesca, Mirante Serena, Greco Beatrice M, Serra Cassano Teresa, Abondio Paolo, Canterini Sonia, Malvaso Antonio, Grecucci Alessandro, Citrigno Luigi, Geracitano Silvana, Spadafora Patrizia, Puccio Gianfranco, Frangipane Francesca, Curcio Sabrina M, Ferrise Francesca, Laganà Valentina, Colao Rosanna, Passarino Giuseppe, Bruni Amalia C, Maletta Raffaele, Cavalcanti Francesca, Montesanto Alberto
Abstract excerpt
Recent studies have highlighted the significant role of ADAM17/TACE (encoded by ADAM17/TACE) in the pathogenesis of Alzheimer's disease (AD). Yet, the relationship between ADAM17/TACE gene polymorphisms and AD was less studied. This study aims to analyse the relationship of ADAM17/TACE gene polymorphism with the risk, age of onset, neuropsychiatric manifestations, cognitive impairment, and medial temporal lobe...
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