Genetic association between ADAM10 gene polymorphism and Alzheimer's disease in a Northern Han Chinese population.

doi:10.1016/j.brainres.2011.09.008

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Article

Genetic association between ADAM10 gene polymorphism and Alzheimer's disease in a Northern Han Chinese population.

Brain research - 3 Nov 2011

Song Jing-Hui, Yu Jin-Tai, Liu Min, Yan Chuan-Zhu, Tan Lan

Abstract excerpt

The ADAM10 gene encodes a member of a disintegrin and metalloprotease family, which, after overexpression in Alzheimer's disease (AD), prevents amyloid pathology and improves long-term potentiation and memory. A common polymorphism (rs2305421) within ADAM10 has been recently associated with the risk of developing AD in Europeans. In order to assess the involvement of the ADAM10 polymorphism in the risk of...

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PMID: 21959176
DOI: 10.1016/j.brainres.2011.09.008

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ADAM10

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