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Article

ADAM10 expression and promoter haplotype in Alzheimer's disease.

Neurobiology of aging - 1 Sept 2012

Bekris Lynn M, Lutz Franziska, Li Gail, Galasko Douglas R, Farlow Martin R, Quinn Joseph F, Kaye Jeffrey A, Leverenz James B, Tsuang Debby W, Montine Thomas J, Peskind Elaine R, Yu Chang-En

Abstract excerpt

Alzheimer's disease is confirmed at autopsy according to the accumulation of brain neuritic plaques and neurofibrillary tangles in the brain. Neuritic plaques contain amyloid-β (Aβ) and lower levels of Aβ correspond to an increase in ADAM10 α-secretase activity. ADAM10 α-secretase activity produces a soluble amyloid precursor protein (APP) alpha (sAPPα) product and negates the pathological production of Aβ. In...

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Identifiers

PMID: 22572541
DOI: 10.1016/j.neurobiolaging.2012.03.013
PMCID: PMC3391324

Genes

ADAM10
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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