Article
Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease.
Neurobiology of aging - 1 Feb 2012
Cai Guiqing, Atzmon Gil, Naj Adam C, Beecham Gary W, Barzilai Nir, Haines Jonathan L, Sano Mary, Pericak-Vance Margaret, Buxbaum Joseph D
Abstract excerpt
The Alzheimer amyloid protein precursor (APP) is subject to proteolysis by ADAM10 and ADAM17, precluding the formation of Aβ. Recently, coding variations in ADAM10 resulting in altered function have been reported in familial Alzheimer disease (AD). The authors carried out a large-scale (n = 576: Controls, 271; AD, 305) resequencing study of ADAM10 in sporadic AD. The results do not support a significant role for...
Topics
- ADAM Proteins
- ADAM10 Protein
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Genetic Predisposition to Disease
- Humans
- Membrane Proteins
- Middle Aged
- Mutation
- Polymorphism, Single Nucleotide
- Prevalence