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Genetic association between APP, ADAM10 gene polymorphism, and sporadic Alzheimer's disease in the Chinese population.

Neurotoxicity research - 1 Apr 2015

Zeng Fan, Shen Cheng, Liu Yu-Hui, Li Jing, Zhu Jie, Wang Ye-Ran, Yan Jia-Chuan, Gao Chang-Yue, Zhou Hua-Dong, Deng Juan, Wang Yan-Jiang

Abstract excerpt

Amyloid precursor protein (APP) is cleaved by β-secretase and γ-secretase complex, and subsequently generates amyloid-β peptide (Aβ). The Aβ cascade is widely accepted as playing a role in the pathogenesis Alzheimer's disease (AD). Meanwhile, procession of APP by α-secretase (mainly a disintegrin and metalloproteinase 10, ADAM10) precludes Aβ production, and produces soluble APP-α which is considered to be...

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Source

Identifiers

PMID: 25631235
DOI: 10.1007/s12640-015-9516-1

Genes

APP
ADAM10
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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