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Article

Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease.

Neurobiology of aging - 1 Feb 2008

Lv Haiyan, Jia Longfei, Jia Jianping

Abstract excerpt

Increasing evidence indicates that variants in promoter of the beta-amyloid precursor protein (APP) gene could up-regulate the APP gene expression and aggravate the amyloid beta protein (A beta) accumulation, thus contributing to the development of Alzheimer's disease (AD). In Chinese Han populations we found three polymorphisms in APP promoter: -877T/C(rs466433), -955A/G(rs364048) and -9G/C. The -877T and -955A...

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Identifiers

PMID: 17112637
DOI: 10.1016/j.neurobiolaging.2006.10.001

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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