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Article

No association between the promoter polymorphisms of PAI-1 gene and sporadic Alzheimer's disease in Chinese Han population.

Neuroscience letters - 15 May 2009

Lu Yan, Wang Min, Liu Zheng, Wang Fen, Da Yuwei, Jia Jianping

Abstract excerpt

Amyloid beta peptide (Abeta) accumulation is the major event in the brain of cases with Alzheimer's disease (AD). The serine protease plasmin, which is generated from the inactive zymogen plasminogen, could accelerate Abeta degradation, and thus may play a role in AD pathogenesis. It has been reported that the increasing of plasminogen activator inhibitor-1 (PAI-1) inhibits the activity of plasminogen activator...

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Source

Identifiers

PMID: 19368854
DOI: 10.1016/j.neulet.2009.02.039

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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