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Article

Association between promoter polymorphisms in anterior pharynx-defective-1a and sporadic Alzheimer's disease in the North Chinese Han population.

Neuroscience letters - 15 May 2009

Wang Yan, Jia Jianping

Abstract excerpt

Amyloid beta-peptide (Abeta) deposition in brain is important in the development of sporadic Alzheimer's disease (SAD) and Abeta is produced through sequential cleaving of amyloid precursor protein (APP) by beta-secretase and gamma-secrease. Anterior pharynx-defective-1 (APH-1) is an important subunit of the gamma-secretase complex, and its expression level was associated with the activity of gamma-secrease. We...

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Source

Identifiers

PMID: 19368855
DOI: 10.1016/j.neulet.2009.02.015

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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