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Article

WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2010

Booth C J, Brooks M B, Rockwell S, Murphy J W, Rinder H M, Zelterman D, Paidas M J, Compton S R, Marks P W

Abstract excerpt

BACKGROUND: We recently described an inherited coagulopathy arising in an inbred colony of WAG/RijYcb rats. The bleeding phenotype, demonstrated by both male and female rats, included periarticular hemorrhage, spontaneous bruising, prolonged bleeding from minor wounds and maternal peripartum deaths. Coagulation testing of affected rats revealed normal prothrombin time but prolongation of activated partial...

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Source

Identifiers

PMID: 20626616
DOI: 10.1111/j.1538-7836.2010.03978.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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