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Article

Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality.

Haematologica - 1 Oct 2020

Sluka Susanna H M, Stämpfli Simon F, Akhmedov Alexander, Klein-Rodewald Tanja, Sanz-Moreno Adrián, Horsch Marion, Grest Paula, Rothmeier Andrea S, Rathkolb Birgit, Schrewe Anja, Beckers Johannes, Neff Frauke, Wolf Eckhard, Camici Giovanni G, Fuchs Helmut, Gailus-Durner Valerie, Hrabě de Angelis Martin, Lüscher Thomas F, Ruf Wolfram, Tanner Felix C

Abstract excerpt

Tissue factor is highly expressed in sub-endothelial tissue. The extracellular allosteric disulfide bond Cys186-Cys209 of human tissue factor shows high evolutionary conservation and in vitro evidence suggests that it significantly contributes to tissue factor procoagulant activity. To investigate the role of this allosteric disulfide bond in vivo, we generated a C213G mutant tissue factor mouse by replacing...

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Identifiers

PMID: 33054088
DOI: 10.3324/haematol.2019.218818
PMCID: PMC7556672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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