Article
Clinical and molecular characterization of a re-established line of sheep exhibiting hemophilia A.
Journal of thrombosis and haemostasis : JTH - 1 Feb 2010
Porada C D, Sanada C, Long C R, Wood J A, Desai J, Frederick N, Millsap L, Bormann C, Menges S L, Hanna C, Flores-Foxworth G, Shin T, Westhusin M E, Liu W, Glimp H, Zanjani E D, Lozier J N, Pliska V, Stranzinger G, Joerg H, Kraemer D C, Almeida-Porada G
Abstract excerpt
BACKGROUND: Large animal models that accurately mimic human hemophilia A (HA) are in great demand for developing and testing novel therapies to treat HA. OBJECTIVES: To re-establish a line of sheep exhibiting a spontaneous bleeding disorder closely mimicking severe human HA, fully characterize their clinical presentation, and define the molecular basis for disease. PATIENTS/METHODS: Sequential reproductive...
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