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Article

The F8(-/-) rat as a model of hemophilic arthropathy.

Journal of thrombosis and haemostasis : JTH - 1 Jun 2016

Sørensen K R, Roepstorff K, Wiinberg B, Hansen A K, Tranholm M, Nielsen L N, Kjelgaard-Hansen M

Abstract excerpt

UNLABELLED: Essentials Validating the F8 rat as a new intermediate-size animal model of hemophilic arthropathy. Factor VIII (FVIII) treated F8(-/-) rats suffered induced hemarthrosis analyzed by histopathology. F8 (-/-) animals develop hemophilic arthropathy upon hemarthrosis, preventable by FVIII treatment. The F8 (-/-) rat presents as a new pharmacologic model of hemophilic arthropathy. SUMMARY: Background...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27060449
DOI: 10.1111/jth.13328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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