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Article

The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression.

Blood advances - 14 Jan 2020

Shi Qizhen, Mattson Jeremy G, Fahs Scot A, Geurts Aron M, Weiler Hartmut, Montgomery Robert R

Abstract excerpt

Previous studies have shown that platelet-specific factor VIII (FVIII) expression (2bF8) restores hemostasis and induces immune tolerance in hemophilia A (HA) mice even with preexisting inhibitors. Here we investigated for the first time whether platelet FVIII expression can prevent severe spontaneous bleeding in rat HA, a model mimicking the frequent spontaneous bleeding in patients with severe HA. A novel...

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Identifiers

PMID: 31899798
DOI: 10.1182/bloodadvances.2019000944
PMCID: PMC6960468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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