Molecular basis for complement component 6 (C6) deficiency in rats and mice.

doi:10.1016/j.imbio.2004.08.001

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Molecular basis for complement component 6 (C6) deficiency in rats and mice.

Immunobiology - 1 Jan 2004

Bhole Deepak, Stahl Gregory L

Abstract excerpt

Complement component C6 is a part of the lytic membrane attack complex formed during complement activation. Animal modeling to define the role of C5a vs. C5b-9 in human disease has used rodents deficient in C6, yet the molecular basis for the deficiencies has not been ascertained. Oligonucleotides derived from a 493 bp EST sequence of the rat C6 gene were used to isolate full-length transcripts of rat C6 mRNA....

Topics

Amino Acid Sequence
Animals
Base Sequence
Blood Coagulation Disorders
Complement C6
DNA, Complementary
Humans
Mice
Mice, Inbred C3H
Molecular Sequence Data
Mutation
Point Mutation
Rats

Source

Open in PubMed

Identifiers

PMID: 15568620
DOI: 10.1016/j.imbio.2004.08.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics