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Article

PER3 promoter hypermethylation correlates to the progression of pan-cancer

14 Oct 2024

Abstract excerpt

BACKGROUND: Malignant cells exhibit reduced period circadian regulator 3 (PER3) expression. However, the underlying mechanisms of variations in PER3 expression in cancers and the specific function of PER3 in tumor progression remain poorly understood. RESULTS: We explored multiple public databases, conducted bioinformatics analyses, and performed in vitro and in vivo experiments for validation. We found PER3...

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PMID: 39402618
DOI: 10.1186/s13148-024-01760-5

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