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Article

Structural basis for agonism and antagonism of hepatocyte growth factor.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2010

Tolbert W David, Daugherty-Holtrop Jennifer, Gherardi Ermanno, Vande Woude George, Xu H Eric

Abstract excerpt

Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regeneration but abnormal activation of Met has been implicated in growth, invasion, and metastasis of many types of solid tumors. HGF has two natural splice variants, NK1 and NK2, which contain the N-terminal domain (N) and the first kringle (K1) or the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20624990
DOI: 10.1073/pnas.1005183107
PMCID: PMC2922134

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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