Article
In vivo activation of met tyrosine kinase by heterodimeric hepatocyte growth factor molecule promotes angiogenesis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1995
Silvagno F, Follenzi A, Arese M, Prat M, Giraudo E, Gaudino G, Camussi G, Comoglio P M, Bussolino F
Abstract excerpt
Hepatocyte growth factor (HGF) is a powerful motogen and mitogen for epithelial cells. The factor is a 90-kD heterodimer composed of an alpha chain containing four kringle motifs and a beta chain showing structural homologies with serine proteases. It is, however, devoid of enzymatic activity. Re...
Topics
- Animals
- Base Sequence
- Cell Division
- Cell Movement
- Cells, Cultured
- Drug Synergism
- Endothelium, Vascular
- Enzyme Activation
- Female
- Heparin
- Hepatocyte Growth Factor
- Humans
- Mice
- Mice, Inbred DBA
- Molecular Sequence Data