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Article

State of the structure address on MET receptor activation by HGF.

Biochemical Society transactions - 30 Apr 2021

Linossi Edmond M, Estevam Gabriella O, Oshima Masaya, Fraser James S, Collisson Eric A, Jura Natalia

Abstract excerpt

The MET receptor tyrosine kinase (RTK) and its cognate ligand hepatocyte growth factor (HGF) comprise a signaling axis essential for development, wound healing and tissue homeostasis. Aberrant HGF/MET signaling is a driver of many cancers and contributes to drug resistance to several approved therapeutics targeting other RTKs, making MET itself an important drug target. In RTKs, homeostatic receptor signaling is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33860789
DOI: 10.1042/BST20200394
PMCID: PMC8711257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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