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Article

Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains.

Journal of molecular biology - 23 Mar 2007

Holmes O, Pillozzi S, Deakin J A, Carafoli F, Kemp L, Butler P J G, Lyon M, Gherardi E

Abstract excerpt

Hepatocyte growth factor/scatter factor (HGF/SF), the ligand for the receptor tyrosine kinase encoded by the c-Met proto-oncogene, is a multidomain protein structurally related to the pro-enzyme plasminogen and with major roles in development, tissue regeneration and cancer. We have expressed the N-terminal (N) domain, the four kringle domains (K1 to K4) and the serine proteinase homology domain (SP) of HGF/SF...

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Source

Identifiers

PMID: 17258232
DOI: 10.1016/j.jmb.2006.12.061

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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