Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains.

doi:10.1016/j.jmb.2006.12.061

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains.

Journal of molecular biology - 23 Mar 2007

Holmes O, Pillozzi S, Deakin J A, Carafoli F, Kemp L, Butler P J G, Lyon M, Gherardi E

Abstract excerpt

Hepatocyte growth factor/scatter factor (HGF/SF), the ligand for the receptor tyrosine kinase encoded by the c-Met proto-oncogene, is a multidomain protein structurally related to the pro-enzyme plasminogen and with major roles in development, tissue regeneration and cancer. We have expressed the N-terminal (N) domain, the four kringle domains (K1 to K4) and the serine proteinase homology domain (SP) of HGF/SF...

Topics

Animals
Binding Sites
Cell Line
Cell Movement
Cricetinae
Cricetulus
Dermatan Sulfate
Dogs
Electrophoretic Mobility Shift Assay
Enzyme Activation
Extracellular Signal-Regulated MAP Kinases
Heparitin Sulfate
Hepatocyte Growth Factor

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Kringles

Mice

Mutation

Phosphorylation

Source

Open in PubMed

Identifiers

PMID: 17258232
DOI: 10.1016/j.jmb.2006.12.061

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.