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Article

A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist.

Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2007

Tolbert W David, Daugherty Jennifer, Gao ChongFeng, Xie Qian, Miranti Cindy, Gherardi Ermanno, Vande Woude George, Xu H Eric

Abstract excerpt

Hepatocyte growth factor (HGF) activates the Met receptor tyrosine kinase by binding and promoting receptor dimerization. Here we describe a mechanistic basis for designing Met antagonists based on NK1, a natural variant of HGF containing the N-terminal and the first kringle domain. Through detailed biochemical and structural analyses, we demonstrate that both mouse and human NK1 induce Met dimerization via a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17804794
DOI: 10.1073/pnas.0704290104
PMCID: PMC1965485

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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