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Article

Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 1999

Jiang W G, Hiscox S E, Parr C, Martin T A, Matsumoto K, Nakamura T, Mansel R E

Abstract excerpt

Hepatocyte growth factor (HGF), also known as scatter factor (SF), is known to act on cancer cells as well as endothelial cells and stimulate angiogenesis, thus playing an unwanted role in the development and progression of cancer. The current study examined the effects of a newly discovered HGF variant, NK4, on angiogenesis in vitro. Chemically generated NK4 (from recombinant human HGF/SF) was found to be able...

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Share to Endothelial Growth Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Physiologic

Share to Proto-Oncogene Proteins c-met

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Source

Identifiers

PMID: 10589789

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells.PMID 10589789Read ↗

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Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist.Semantic proximity Read ↗

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