Article
Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes.
The Journal of allergy and clinical immunology - 1 Sept 2010
O'Regan Gráinne M, Kemperman Patrick M J H, Sandilands Aileen, Chen Huijia, Campbell Linda E, Kroboth Karin, Watson Rosemarie, Rowland Marion, Puppels Gerwin J, McLean W H Irwin, Caspers Peter J, Irvine Alan D
Abstract excerpt
BACKGROUND: Filaggrin (FLG) has a central role in the pathogenesis of atopic dermatitis (AD). FLG is a complex repetitive gene; highly population-specific mutations and multiple rare mutations make routine genotyping complex. Furthermore, the mechanistic pathways through which mutations in FLG predispose to AD are unclear. OBJECTIVES: We sought to determine whether specific Raman microspectroscopic natural...
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