Deep palmar phenotyping in atopic eczema: patterns associated with filaggrin variants, disease severity and barrier function in a South Asian population.

doi:10.1093/bjd/ljad036

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Article

Deep palmar phenotyping in atopic eczema: patterns associated with filaggrin variants, disease severity and barrier function in a South Asian population.

The British journal of dermatology - 24 May 2023

Thomas Bjorn R, Tan Xiang Li, Van Duijvenboden Stefan, Hogan Sarah C, Hughes Aaron J, Tawfik Soha S, Dhoat Sasha, Atkar Ravinder, Robinson Elizabeth J, Rahman Syedia R, Rahman Samiha, Ahmed Rehana A, Begum Rubina, Khanam Habiba, Bourne Emma L, Wozniak Eva L, Mein Charles A, Kelsell David P, O'Toole Edel A

Abstract excerpt

BACKGROUND: Hyperlinear palms are described as a feature of loss-of-function (LoF) variants in filaggrin (FLG). OBJECTIVES: To explore the phenotype of participants (age < 31 years) with atopic eczema of Bangladeshi ancestry from East London and investigate which factors best associate with LoF FLG variants. METHODS: A cross-sectional study with participants recruited between May 2018 and December 2020. Patterns...

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PMID: 36840480
DOI: 10.1093/bjd/ljad036

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