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Article

In vivo Raman spectroscopy discriminates between FLG loss-of-function carriers vs wild-type in day 1-4 neonates.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 1 May 2020

Ní Chaoimh Carol, Nico Claudio, Puppels Gerwin J, Caspers Peter J, Wong X F Colin C, Common John E, Irvine Alan D, Hourihane Jonathan O'B

Abstract excerpt

BACKGROUND: Carriers of loss-of-function mutations in the filaggrin gene (LoF FLG) have less natural moisturizing factor (NMF) in their stratum corneum (SC) and an increased risk of atopic dermatitis (AD). Natural moisturizing factor can be measured noninvasively by Raman spectroscopy. The use of Raman-derived NMF at birth to screen for FLG genotype could inform targeted AD prevention, but values in neonatal...

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PMID: 32035937
DOI: 10.1016/j.anai.2020.01.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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