Article
Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study.
Steroids - 1 Dec 2010
Siemes Claire, Visser Loes E, de Jong Frank H, Coebergh Jan-Willem W, Uitterlinden André G, Hofman Albert, Stricker Bruno H Ch, van Schaik Ron H N
Abstract excerpt
PURPOSE: To study if polymorphisms in genes encoding for CYP3A enzymes, that play a role in steroid hormone metabolism, affect steroid hormone serum levels and prostate cancer incidence or mortality. METHODS: 3048 male participants of The Rotterdam Study were included. Prostate cancer cases and non-cases were studied for differences in baseline hormone levels with Student's t-test. General linear models were...
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