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Article

Association of CYP3A5*3 polymorphisms and prostate cancer risk: A meta-analysis.

Journal of cancer research and therapeutics - 1 Jun 2018

Liang Ying, Han Wen, Yan Hongwei, Mao Qiqi

Abstract excerpt

AIM OF STUDY: The CYP3A5*3 allele (A6986G transition in intron 3) is the major member of cytochrome P450 subfamily, which plays a pivotal role in exogenous carcinogens of liver. Variation of the CYP3A5*3 (rs776746 A > G) can lead to oxidation and inactivation of testosterone, which may result in individual susceptibility to prostate cancer. METHODS: All eligible published studies about association between...

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PMID: 29970707
DOI: 10.4103/0976-7800.179173

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