Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP3A4 polymorphisms--potential risk factors for breast and prostate cancer: a HuGE review.

American journal of epidemiology - 1 Nov 2004

Keshava Channa, McCanlies Erin C, Weston Ainsley

Abstract excerpt

The steroid hydroxylase CYP3A4 is the most abundant P-450 enzyme in the human liver, and CYP3A enzymes metabolize more than 50% of prescription drugs. The CYP3A4 gene is expressed in the liver, gut, colon, prostate, and breast. Individual variation in CYP3A4 may play a role in breast and prostate carcinogenesis through modulation of sex hormone metabolite levels. Alternatively, CYP3A4 can metabolically activate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androgens
Share to Australia
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogens

Share to Cytochrome P-450 CYP3A

Share to Cytochrome P-450 Enzyme System

Share to Epidemiologic Studies

Share to Scotland

Source

Identifiers

PMID: 15496535
DOI: 10.1093/aje/kwh294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP3A4 polymorphisms--potential risk factors for breast and prostate cancer: a HuGE review.PMID 15496535Read ↗

CYP3A4*1B polymorphism and cancer risk: a HuGE review and meta-analysis.Semantic proximity Read ↗

Correlations between CYP3A4 polymorphism and susceptibility to breast cancer in Chinese Han population.Semantic proximity Read ↗

Polymorphisms in drug-metabolizing genes and urinary bladder cancer susceptibility and prognosis: Possible impacts and future management.Semantic proximity Read ↗

CYP3A4: a potential prostate cancer risk factor for high-risk groups.Semantic proximity Read ↗

Genetic polymorphism of metabolic enzymes P450 (CYP) as a susceptibility factor for drug response, toxicity, and cancer risk.Semantic proximity Read ↗

[Molecular epidemiology and cancer prevention].Semantic proximity Read ↗

Cytochrome P450 gene polymorphism and cancer.Semantic proximity Read ↗

Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and AtherosclerosisSemantic proximity Read ↗

Allelic variants in xenobiotic metabolism genes predict susceptibility and worse prognosis of urothelial bladder cancerSemantic proximity Read ↗

Human Cytochrome P450 Cancer-Related Metabolic Activities and Gene PolymorphismsSemantic proximity Read ↗

Polymorphism of CYP450 and cancer susceptibility.Semantic proximity Read ↗

Genetic association in CYP3A4 and CYP3A5 genes elevate the risk of prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.