Article
Inherited variation in hormone-regulating genes and prostate cancer survival.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2007
Lindström Sara, Adami Hans-Olov, Bälter Katarina Augustsson, Xu Jianfeng, Zheng S Lilly, Stattin Pär, Grönberg Henrik, Wiklund Fredrik
Abstract excerpt
PURPOSE: Hormonal manipulation is the mainstay treatment of prostate cancer, notably in advanced stages. Despite initial favorably response, the cancer eventually develops hormone resistance resulting in disease progression and death. However, little is known about genetic determinants of disease progression and prostate cancer-specific death. EXPERIMENTAL DESIGN: We analyzed a population-based cohort comprising...
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