Article
Comprehensive analysis of hormone and genetic variation in 36 genes related to steroid hormone metabolism in pre- and postmenopausal women from the breast and prostate cancer cohort consortium (BPC3).
The Journal of clinical endocrinology and metabolism - 1 Feb 2011
Beckmann L, Hüsing A, Setiawan V W, Amiano P, Clavel-Chapelon F, Chanock S J, Cox D G, Diver R, Dossus L, Feigelson H S, Haiman C, Hallmans G, Hayes R B, Henderson B E, Hoover R N, Hunter D J, Khaw K, Kolonel L N, Kraft P, Lund E, Le Marchand L, Peeters P H M, Riboli E, Stram D, Thomas G, Thun M J, Tumino R, Trichopoulos D, Vogel U, Willett W C, Yeager M, Ziegler R, Hankinson S E, Kaaks R
Abstract excerpt
CONTEXT: Sex steroids play a central role in breast cancer development. OBJECTIVE: This study aimed to relate polymorphic variants in 36 candidate genes in the sex steroid pathway to serum concentrations of sex steroid hormones and SHBG. DESIGN: Data on 700 genetic polymorphisms were combined with existing hormone assays and data on breast cancer incidence, within the European Prospective Investigation into...
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