CYP3A variation, premenopausal estrone levels, and breast cancer risk.

doi:10.1093/jnci/djs156

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Article

CYP3A variation, premenopausal estrone levels, and breast cancer risk.

Journal of the National Cancer Institute - 2 May 2012

Johnson Nichola, Walker Kate, Gibson Lorna J, Orr Nick, Folkerd Elizabeth, Haynes Ben, Palles Claire, Coupland Ben, Schoemaker Minouk, Jones Michael, Broderick Peter, Sawyer Elinor, Kerin Michael, Tomlinson Ian P, Zvelebil Marketa, Chilcott-Burns Sarah, Tomczyk Katarzyna, Simpson Gemma, Williamson Jill, Hillier Stephen G, Ross Gillian, Houlston Richard S, Swerdlow Anthony, Ashworth Alan, Dowsett Mitch, Peto Julian, Dos Santos Silva Isabel, Fletcher Olivia

Abstract excerpt

BACKGROUND: Epidemiological studies have provided strong evidence for a role of endogenous sex steroids in the etiology of breast cancer. Our aim was to identify common variants in genes involved in sex steroid synthesis or metabolism that are associated with hormone levels and the risk of breast cancer in premenopausal women. METHODS: We measured urinary levels of estrone glucuronide (E1G) using a protocol...

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PMID: 22472546
DOI: 10.1093/jnci/djs156

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