Article
Regional increase in P-glycoprotein function in the blood-brain barrier of patients with chronic schizophrenia: a PET study with [(11)C]verapamil as a probe for P-glycoprotein function.
Psychiatry research - 30 Aug 2010
de Klerk Onno L, Willemsen Antoon T M, Bosker Fokko J, Bartels Anna L, Hendrikse N Harry, den Boer Johan A, Dierckx Rudy A
Abstract excerpt
P-glycoprotein (P-gp), a major efflux pump in the blood-brain barrier (BBB) has a profound effect on entry of drugs, peptides and other substances into the central nervous system (CNS). The brain's permeability can be negatively influenced by modulation of the transport function of P-gp. Inflammatory mediators play a role in schizophrenia, and may be able to influence the integrity of the BBB, via P-gp...
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