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PET and SPECT Radiotracers to Assess Function and Expression of ABC Transporters In Vivo

1 Oct 2011

Abstract excerpt

Adenosine triphosphate-binding cassette (ABC) transporters, such as P-glycoprotein (Pgp, ABCB1), breast cancer resistance protein (BCRP, ABCG2) and multidrug resistance-associated proteins (MRPs) are expressed in high concentrations at various physiological barriers (e.g. blood-brain barrier, blood-testis barrier, blood-tumor barrier), where they impede the tissue accumulation of various drugs by active efflux...

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PMID: 21434859
DOI: 10.2174/138920011798356980

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