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Article

Differential pharmacological regulation of drug efflux and pharmacoresistant schizophrenia

15 Jan 2008

Abstract excerpt

Pharmacoresistant schizophrenia is a significant impediment to the successful management of the disease. The expression and function of P-glycoprotein (P-gp) has recently been implicated in this phenomenon. P-gp is a multidrug efflux transporter that prevents drug substrates from crossing the blood-brain barrier (BBB). Although the direct interaction between individual antipsychotic agents and P-gp has been...

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PMID: 18200566
DOI: 10.1002/bies.20706

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