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Article

Influence of functional haplotypes in the drug transporter gene on central nervous system drug distribution in humans

1 Aug 2005

Abstract excerpt

BACKGROUND AND OBJECTIVE: Single nucleotide polymorphisms in the human multidrug-resistance gene ABCB1 have been reported to be associated with altered expression and function of P-glycoprotein, an efflux transporter, expressed at the blood-brain barrier. To test whether certain ABCB1 haplotypes contribute to interindividual differences in central nervous system drug distribution, brain distribution of a model...

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PMID: 16084852
DOI: 10.1016/j.clpt.2005.04.011

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