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Article

Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Sept 2006

Takano Akihiro, Kusuhara Hiroyuki, Suhara Tetsuya, Ieiri Ichiro, Morimoto Takuya, Lee Young-Joo, Maeda Jun, Ikoma Yoko, Ito Hiroshi, Suzuki Kazutoshi, Sugiyama Yuichi

Abstract excerpt

UNLABELLED: P-glycoprotein (P-gp) is a membrane protein that functions as an adenosine triphosphate-dependent efflux pump for xenobiotics at the blood-brain barrier (BBB). Polymorphisms of MDR1 gene have been reported to be associated with the expression level of P-gp. (11)C-Verapamil is considered to be one of the suitable radioligands for evaluating P-gp functions. However, the metabolites of verapamil might...

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PMID: 16954549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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