Article
Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development.
PLoS genetics - 1 Oct 2017
Ridge Liam A, Mitchell Karen, Al-Anbaki Ali, Shaikh Qureshi Wasay Mohiuddin, Stephen Louise A, Tenin Gennadiy, Lu Yinhui, Lupu Irina-Elena, Clowes Christopher, Robertson Abigail, Barnes Emma, Wright Jayne A, Keavney Bernard, Ehler Elisabeth, Lovell Simon C, Kadler Karl E, Hentges Kathryn E
Abstract excerpt
The coronary vasculature is an essential vessel network providing the blood supply to the heart. Disruptions in coronary blood flow contribute to cardiac disease, a major cause of premature death worldwide. The generation of treatments for cardiovascular disease will be aided by a deeper understanding of the developmental processes that underpin coronary vessel formation. From an ENU mutagenesis screen, we have...
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