Article
Biological properties and structure of the lipopolysaccharide of a vaccine strain of Francisella tularensis generated by inactivation of a quorum sensing system gene qseC.
Biochemistry. Biokhimiia - 1 Apr 2010
Mokrievich A N, Kondakova A N, Valade E, Platonov M E, Vakhrameeva G M, Shaikhutdinova R Z, Mironova R I, Blaha D, Bakhteeva I V, Titareva G M, Kravchenko T B, Kombarova T I, Vidal D, Pavlov V M, Lindner B, Dyatlov I A, Knirel Yu A
Abstract excerpt
A knockout mutant with a deletion in a quorum sensing system gene qseC was generated from the vaccine strain Francisella tularensis 15 by site-directed mutagenesis. The variant with the inactivated gene qseC differed from the parental strain in growth rate on solid nutrient medium but had the same growth dynamics in liquid nutrient medium. The mutation abolished almost completely the resistance of the vaccine...
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