Article
A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity.
Infection and immunity - 1 May 2007
Sebastian Shite, Dillon Simon T, Lynch Jillian G, Blalock LeeAnn T, Balon Emmy, Lee Kristin T, Comstock Laurie E, Conlan J Wayne, Rubin Eric J, Tzianabos Arthur O, Kasper Dennis L
Abstract excerpt
Francisella tularensis, the causative agent of tularemia, has been designated a CDC category A select agent because of its low infective dose (<10 CFU), its ready transmission by aerosol, and its ability to produce severe morbidity and high mortality. The identification and characterization of this organism's virulence determinants will facilitate the development of a safe and effective vaccine. We report that...
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