Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a live attenuated vaccine candidate for tularemia prophylaxis.

PloS one - 1 Jan 2013

Mahawar Manish, Rabadi Seham M, Banik Sukalyani, Catlett Sally V, Metzger Dennis W, Malik Meenakshi, Bakshi Chandra Shekhar

Abstract excerpt

Francisella tularensis is the causative agent of a fatal human disease, tularemia. F. tularensis was used in bioweapon programs in the past and is now classified as a category A select agent owing to its possible use in bioterror attacks. Despite over a century since its discovery, an effective vaccine is yet to be developed. In this study four transposon insertion mutants of F. tularensis live vaccine strain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Formation
Share to Bacterial Vaccines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Francisella tularensis

Share to Immunity, Humoral

Share to Immunization

Share to Microbial Viability

Share to Tularemia

Share to Vaccines, Attenuated

Source

Open in PubMed Open full text

Identifiers

PMID: 23613871
DOI: 10.1371/journal.pone.0061539
PMCID: PMC3629233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a live attenuated vaccine candidate for tularemia prophylaxis.PMID 23613871Read ↗

Vaccines against Francisella tularensis.Semantic proximity Read ↗

Adaptive Immunity to Francisella tularensis and Considerations for Vaccine DevelopmentSemantic proximity Read ↗

Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strain.Semantic proximity Read ↗

A Francisella tularensis Live Vaccine Strain (LVS) Mutant with a Deletion in capB , Encoding a Putative Capsular Biosynthesis Protein, Is Significantly More Attenuated than LVS yet Induces Potent Protective Immunity in Mice against F. tularensis ChallengeSemantic proximity Read ↗

A vaccine for tularaemia.Semantic proximity Read ↗

Low dose vaccination with attenuated Francisella tularensis strain SchuS4 mutants protects against tularemia independent of the route of vaccination.Semantic proximity Read ↗

A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine.Semantic proximity Read ↗

Identification of a Novel Francisella tularensis Factor Required for Intramacrophage Survival and Subversion of Innate Immune ResponseSemantic proximity Read ↗

Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: Identification of candidate epitopes for inclusion in a rationally designed tularemia vaccineSemantic proximity Read ↗

In vivo Himar1-based transposon mutagenesis of Francisella tularensis.Semantic proximity Read ↗

Use of transposon-transposase complexes to create stable insertion mutant strains of Francisella tularensis LVS.Semantic proximity Read ↗

EmrA1 membrane fusion protein of Francisella tularensis LVS is required for resistance to oxidative stress, intramacrophage survival and virulence in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.