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Article

SILAC-based proteomic analysis to dissect the "histone modification signature" of human breast cancer cells.

Amino acids - 1 Jul 2011

Cuomo Alessandro, Moretti Simona, Minucci Saverio, Bonaldi Tiziana

Abstract excerpt

In living cells, the N-terminal tails of core histones, the proteinaceous component of nucleosomes, are subjected to a range of covalent post-translational modifications (PTMs), which have specific roles in modulating chromatin structure and function. A growing body of evidence suggests that deregulation of histone modification patterns, upstream or downstream of DNA methylation, is a critical event in cancer...

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Source

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PMID: 20617350
DOI: 10.1007/s00726-010-0668-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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