Article
Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome.
Cancer research - 1 May 2009
Elsheikh Somaia E, Green Andrew R, Rakha Emad A, Powe Des G, Ahmed Rabab A, Collins Hilary M, Soria Daniele, Garibaldi Jonathan M, Paish Claire E, Ammar Amr A, Grainge Matthew J, Ball Graham R, Abdelghany Magdy K, Martinez-Pomares Luisa, Heery David M, Ellis Ian O
Abstract excerpt
Post-translational histone modifications are known to be altered in cancer cells, and loss of selected histone acetylation and methylation marks has recently been shown to predict patient outcome in human carcinoma. Immunohistochemistry was used to detect a series of histone lysine acetylation (H3K9ac, H3K18ac, H4K12ac, and H4K16ac), lysine methylation (H3K4me2 and H4K20me3), and arginine methylation (H4R3me2)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.