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Article

Modifications of human histone H3 variants during mitosis.

Biochemistry - 4 Oct 2005

Garcia Benjamin A, Barber Cynthia M, Hake Sandra B, Ptak Celeste, Turner Fiona B, Busby Scott A, Shabanowitz Jeffrey, Moran Richard G, Allis C David, Hunt Donald F

Abstract excerpt

Phosphorylation of histone H3 is a hallmark event in mitosis and is associated with chromosome condensation. Here, we use a combination of immobilized metal affinity chromatography and tandem mass spectrometry to characterize post-translational modifications associated with phosphorylation on the N-terminal tails of histone H3 variants purified from mitotically arrested HeLa cells. Modifications observed in vivo...

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Identifiers

PMID: 16185088
DOI: 10.1021/bi050906n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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